e0201 Heat shock protein 90 protects rat mesenchymal stem cells against hypoxia and serum deprivationinduced apoptosis via PI3KAkt and ERK12 pathways
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چکیده
منابع مشابه
Nicorandil protects mesenchymal stem cells against hypoxia and serum deprivation-induced apoptosis
Nicorandil, an adenosine triphosphate (ATP)-sensitive potassium (K(ATP)) channel opener, has been shown to exert a significant protective effect against ischemic heart injury. In the present study, we investigated the anti-apoptotic effects of nicorandil on rat mesenchymal stem cells (MSCs) subjected to hypoxia and serum deprivation (H/SD), as well as the potential underlying mechanisms. Apopto...
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Mesenchymal stem cells (MSCs) have the potential to facilitate cardiac repair following acute myocardial infarction. However, MSC therapy is limited by apoptosis of the stem cells following transplantation. Hydrogen sulfide (H2S) has recently been proposed as an endogenous mediator of cell apoptosis in various systems. The aim of the present study was to investigate the mechanism underlying the...
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ژورنال
عنوان ژورنال: Heart
سال: 2010
ISSN: 1355-6037
DOI: 10.1136/hrt.2010.208967.201